[HTML][HTML] Using protein-protein interactions to identify novel genes and demonstrate the interconnected network formation of genes in Retinitis Pigmentosa …

SB Yoon, A Venkat, CYA Liu… - … Ophthalmology & Visual …, 2021 - iovs.arvojournals.org
Purpose: Retinitis Pigmentosa (RP) is a rare monogenic retinal disease that causes the
atrophy of photoreceptor, cone and rod cells. Based on the defect of even a single causal gene …

[HTML][HTML] Applying Protein–Protein Interactions and Complex Networks to Identify Novel Genes in Retinitis Pigmentosa Pathogenesis

SB Yoon, YC Ma, A Venkat, CY Liu… - International journal of …, 2022 - mdpi.com
Retinitis Pigmentosa (RP) is a hereditary retinal disorder that causes the atrophy of
photoreceptor rod cells. Since individual defective genes converge on the same disease, we …

Omega-3 polyunsaturated fatty acids in cardiovascular diseases comorbid major depressive disorder–Results from a randomized controlled trial

…, SS Chang, HT Yang, HT Chen, YC Chien… - Brain, behavior, and …, 2020 - Elsevier
Introduction Cardiovascular diseases (CVDs) and major depressive disorder (MDD) will be
the two most disabling diseases by 2030. Patients with CVDs comorbid depression had …

Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities

…, TJ Metzner, JT Leppert, Y Chien… - Proceedings of the …, 2021 - National Acad Sciences
Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens
but are generally inactive, although they often show signs of prior clonal expansion. …

[HTML][HTML] IDC theory: creation and the creation loop

…, JL Shih, YT Wu, SC Kong, L Wu, TC Chien… - Research and Practice …, 2019 - Springer
The interest-driven creator (IDC) theory is being developed as a group endeavor by Asian
researchers to articulate a holistic learning design theory for future education in Asia. The …

Deep Q-Learning for Trading Cryptocurrency

Z Wang, A Fleiss - The Journal of Financial Data Science, 2021 - pm-research.com
This article sets forth a framework for deep reinforcement learning as applied to trading
cryptocurrencies. Specifically, the authors adopt Q-Learning, which is a model-free reinforcement …

Current developments of computer-aided drug design

HJ Huang, HW Yu, CY Chen, CH Hsu, HY Chen… - Journal of the Taiwan …, 2010 - Elsevier
The continuous advancement in molecular biology and information technology aided the
development of a rich molecular simulation repertoire that can be applied in system biology, …

[HTML][HTML] Inhibition of arachidonate 12/15-lipoxygenase improves α-galactosidase efficacy in iPSC-derived cardiomyocytes from fabry patients

Y Chien, SJ Chou, YL Chang, HB Leu… - International journal of …, 2018 - mdpi.com
(1) Background: A high incidence of intervening sequence (IVS)4+919 G>A mutation with
later-onset cardiac phenotype have been reported in a majority of Taiwan Fabry cohorts. Some …

[PDF][PDF] Plant cytosolic ascorbate peroxidase with dual catalytic activity modulates abiotic stress tolerances

DC Chin, RS Kumar, CS Suen, CY Chien, MJ Hwang… - Iscience, 2019 - cell.com
Ascorbic acid-glutathione (AsA-GSH) cycle represents important antioxidant defense system
in planta. Here we utilized Oncidium cytosolic ascorbate peroxidase (OgCytAPX) as a …

[HTML][HTML] Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+ 919 G> …

Y Chien, CS Chien, HC Chiang, WL Huang, SJ Chou… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Yu Q, Vazquez R, Khojeini EV, Patel C, Venkataramani R, Larson DF. IL-18 induction of
osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice. Am J Physiol Heart …