Background A trial involving adults 50 years of age or older (ZOE-50) showed that the herpes
zoster subunit vaccine (HZ/su) containing recombinant varicella–zoster virus glycoprotein …

Objective To develop Clinical Practice Guidelines for the screening, assessment and management
of the geriatric condition of frailty. Methods An adapted Grading of Recommendations…

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Adenosine can be released from a variety of cells throughout the body, as the result of increased
metabolic rates, in concentrations that can have a profound impact on the vasculature, …

The study examined social network types in a sample of 1,005 older Chinese adults in Hong
Kong and the networks’ relations to subjective well-being. Given the nature of kinship in …

Purpose: Adenosine is a ubiquitous nucleoside that accumulates at high levels in hypoxic
regions of solid tumors, and A 3 adenosine receptors have been recently demonstrated to play …

Frequent coffee consumption has been associated with a reduced risk of colorectal cancer
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …

Background Epidemiologic evidence suggests that cognitive and physical activities are
associated with better cognition in late life. The present study was conducted to examine the …

Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it
may also induce apoptosis and impair cell survival. Following the pharmacologic …

The antagonistic interaction between adenosine and dopamine receptors could have
important pathophysiological and therapeutic implications in Parkinson's disease (PD). The …