User profiles for Andrew Sinclair

Andrew J Sinclair

Emeritus Professor, Deakin University
Verified email at deakin.edu.au
Cited by 25836

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

AH Sinclair, P Berta, MS Palmer, JR Hawkins… - Nature, 1990 - nature.com
A search of a 35-kilobase region of the human Y chromosome necessary for male sex
determination has resulted in the identification of a new gene. This gene is conserved and Y-…

A male-specific role for SOX9 in vertebrate sex determination

J Kent, SC Wheatley, JE Andrews, AH Sinclair… - …, 1996 - journals.biologists.com
Mutation analyses of patients with campomelic dysplasia, a bone dysmorphology and XY
sex reversal syndrome, indicate that the SRY-related gene SOX9 is involved in both skeletal …

Genetic evidence equating SRY and the testis-determining factor

P Berta, JB Hawkins, AH Sinclair, A Taylor, BL Griffiths… - Nature, 1990 - nature.com
THE testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for
initiating male sex determination. SRY is a gene located in the sex-determining region of the …

α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

JT Brenna, N Salem Jr, AJ Sinclair… - … leukotrienes and essential …, 2009 - Elsevier
Blood levels of polyunsaturated fatty acids (PUFA) are considered biomarkers of status.
Alpha-linolenic acid, ALA, the plant omega-3, is the dietary precursor for the long-chain omega-3 …

The avian Z-linked gene DMRT1 is required for male sex determination in the chicken

…, DM Cummins, PG Farlie, TJ Doran, AH Sinclair - Nature, 2009 - nature.com
Sex in birds is chromosomally based, as in mammals, but the sex chromosomes are different
and the mechanism of avian sex determination has been a long-standing mystery 1 , 2 , 3 . …

Dietary intakes and food sources of omega‐6 and omega‐3 polyunsaturated fatty acids

BJ Meyer, NJ Mann, JL Lewis, GC Milligan, AJ Sinclair… - Lipids, 2003 - Wiley Online Library
Both n−6 and n−3 polyunsaturated fatty acids (PUFA) are recognized as essential nutrients
in the human diet, yet reliable data on population intakes are limited. The aim of the present …

Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression

PB Adams, S Lawson, A Sanigorski, AJ Sinclair - Lipids, 1996 - Wiley Online Library
In this study of 20 moderately to severely depressed patients, diagnosed using current
research diagnostic criteria and excluding known bipolar affective disorder and reactive …

[HTML][HTML] The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

…, P Nestel, U Riserus, T Sanders, A Sinclair… - The American journal of …, 2011 - Elsevier
Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs)
to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. …

[HTML][HTML] Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function

…, MJ Pike, AH Turner, NJ Mann, AJ Sinclair - The American journal of …, 2003 - Elsevier
Background: Flavonoids may be partly responsible for some health benefits, including
antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of flavanols …

Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial

…, H Li, R Wang, J Tang, T Huang, J Zheng, AJ Sinclair… - Gut, 2019 - gut.bmj.com
Objective to investigate whether diets differing in fat content alter the gut microbiota and faecal
metabolomic profiles, and to determine their relationship with cardiometabolic risk factors …